Could this be caused by the metoprolol even though the buzzing hasn t happened until now.

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Be careful driving or operating machinery until you know how TOPROL-XL affects you.

If clonidine and a beta blockersuch as metoprolol are coadministeredwithdraw the beta-blocker several days before the gradual withdrawal of clonidine because beta-blockers may exacerbate the rebound hypertension that can follow the withdrawal of clonidineIf replacing clonidine by betablocker therapydelay the introduction of beta-blockers for several days after clonidine administration has stoppedsee WARNINGS AND PRECAUTIONS

If you have not told your doctor about any of these thingstell them before you take TOPROL-XL.

HypotensionTreat underlying bradycardiaConsider intravenous vasopressor infusionsuch as dopamine or norepinephrine.

Numerous antihypertensive drugsfrom a variety of pharmacologic classes and with different mechanisms of actionhave been shown in randomized controlled trials to reduce cardiovascular morbidity and mortalityand it can be concluded that it is blood pressure reductionand not some other pharmacologic property of the drugsthat is largely responsible for those benefitsThe largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of strokebut reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.

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